Morse H C, Morawetz R A, Giese N A, Chattopadhyay S K, Tang Y, Fredrickson T N, Hartley J W
Laboratory of Immunopathology, NIAID, NIH, Bethesda, MD 20892, USA.
Leukemia. 1997 Apr;11 Suppl 3:167-9.
The mechanisms responsible for development of profound immunodeficiency and extensive lymphoproliferation that characterize infection of different species with retroviruses are only partially understood. In mice, it has been shown the activities of an unusual Gag protein are necessary and sufficient to induce these abnormalities in a syndrome designated mouse AIDS (MAIDS). Current studies suggest that complex, antigen-driven interactions between T cells and B cells result in polyclonal activation of both types of lymphocytes, aberrant cytokine production and late lymphomas.
不同物种感染逆转录病毒后所表现出的严重免疫缺陷和广泛淋巴细胞增殖的发病机制仅得到部分理解。在小鼠中，已证明一种异常的Gag蛋白的活性对于在一种称为小鼠艾滋病（MAIDS）的综合征中诱导这些异常是必要且充分的。目前的研究表明，T细胞和B细胞之间复杂的、抗原驱动的相互作用导致这两种淋巴细胞的多克隆激活、细胞因子产生异常以及晚期淋巴瘤。
