Selvey L A, Morse H C, Granger L G, Hodes R J
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
J Immunol. 1993 Aug 1;151(3):1712-22.
Infection of B6 mice with LP-BM5 MuLV results in a syndrome characterized by progressive and profound immunodeficiency, termed murine acquired immunodeficiency syndrome (MAIDS). In this report we show that preferential expansion and activation of V beta 5+ CD4+ spleen cells occurs early in the course of disease, which then progresses to more widespread polyclonal activation of CD4+ T cells. V beta 5 expansion occurs only on infection with MAIDS-associated MuLV and is not observed after infection with other MuLV. The possible role of V beta 5 activation and expansion as a necessary early step in the pathogenesis of MAIDS is discussed.
用LP - BM5 MuLV感染B6小鼠会导致一种以进行性和严重免疫缺陷为特征的综合征，称为小鼠获得性免疫缺陷综合征（MAIDS）。在本报告中，我们表明Vβ5 + CD4 +脾细胞的优先扩增和激活在疾病过程早期就会发生，随后发展为更广泛的CD4 + T细胞多克隆激活。Vβ5扩增仅在感染与MAIDS相关的MuLV时出现，感染其他MuLV后未观察到。本文讨论了Vβ5激活和扩增作为MAIDS发病机制中必要早期步骤的可能作用。
