Bramblett D, Liu J, Lozano M, Xu L, Wrona T, Rajan L, Ross S R, Dudley J
Dept. of Microbiology, University of Pennsylvania Medical School, Philadelphia 19104, USA.
Leukemia. 1997 Apr;11 Suppl 3:183-6.
Mouse mammary tumor virus (MMTV) causes mammary carcinomas and T-cell tumors in mice. MMTV variants that induce T-cell tumors have a large deletion within the U3 region of the long terminal repeat (LTR) compared to MMTV strains that induce mammary tumors. We provide evidence here that T-cell tropic MMTV strains lack a redundant binding site for a cellular protein called NBP (negative regulatory element binding protein). The lack of NBP-binding sites in T-cell tropic MMTV strains presumably leads to higher levels of transcription in T-cells during the MMTV life cycle and an increased incidence of mutagenic integration events.
小鼠乳腺肿瘤病毒（MMTV）可引发小鼠的乳腺癌和T细胞肿瘤。与诱发乳腺肿瘤的MMTV毒株相比，诱发T细胞肿瘤的MMTV变体在长末端重复序列（LTR）的U3区域内有大片段缺失。我们在此提供证据表明，嗜T细胞的MMTV毒株缺乏一种名为NBP（负调控元件结合蛋白）的细胞蛋白的冗余结合位点。嗜T细胞的MMTV毒株中缺乏NBP结合位点，可能会导致MMTV生命周期中T细胞内转录水平升高以及诱变整合事件的发生率增加。
