Morgan S M, Roberts S H, Thompson P W, De Alwis C
Institute of Medical Genetics, University Hospital of Wales Healthcare NHS Trust, Heath Park, Cardiff, United Kingdom.
Cancer Genet Cytogenet. 1997 Jul 1;96(1):13-6. doi: 10.1016/s0165-4608(96)00265-8.
We report a case of splenic lymphoma with villous lymphocytes showing a karyotype with an isochromosome for both the long arm and the short arm of chromosome 12, i(12)(p10) and i(12)(q10), effectively resulting in trisomy 12. This is, apparently, the first documented case of an additional copy of chromosome 12 resulting from isochromosome formation in a neoplastic disorder.
我们报告了一例伴有绒毛状淋巴细胞的脾淋巴瘤病例，其核型显示12号染色体长臂和短臂均有等臂染色体，即i(12)(p10)和i(12)(q10)，实际上导致了12号染色体三体。显然，这是第一例有文献记载的因等臂染色体形成导致肿瘤性疾病中出现额外一条12号染色体的病例。
