精神分裂症和分裂情感性障碍患者的脑脊液神经降压素浓度与抗精神病药物治疗
CSF neurotensin concentrations and antipsychotic treatment in schizophrenia and schizoaffective disorder.
作者信息
Sharma R P, Janicak P G, Bissette G, Nemeroff C B
机构信息
Department of Psychiatry, University of Illinois College of Medicine at Chicago 60612, USA.
出版信息
Am J Psychiatry. 1997 Jul;154(7):1019-21. doi: 10.1176/ajp.154.7.1019.
OBJECTIVE
The relationship between CSF neurotensin concentrations and measures of psychopathology in patients with schizophrenia or schizoaffective disorder was examined before and after treatment with antipsychotic drugs.
METHOD
CSF neurotensin concentrations were measured in 42 drug-free patients with schizophrenia or schizoaffective disorder. For 18 of these patients, CSF neurotensin was measure again after 4 weeks of antipsychotic treatment.
RESULTS
Significantly higher levels of pretreatment psychopathology were observed in the patients with the lowest CSF neurotensin concentrations. Furthermore, improvements in overall psychopathology and, particularly, negative symptoms were correlated with increases in CSF neurotensin concentrations during treatment.
CONCLUSIONS
These findings provide further evidence for a role of neurotensin the pathophysiology of psychosis and in the mechanism of action of antipsychotic drugs.
目的
在使用抗精神病药物治疗前后，研究精神分裂症或分裂情感性障碍患者脑脊液中神经降压素浓度与精神病理学指标之间的关系。
方法
对42例未服用药物的精神分裂症或分裂情感性障碍患者测量脑脊液中神经降压素浓度。其中18例患者在接受4周抗精神病药物治疗后再次测量脑脊液中神经降压素浓度。
结果
脑脊液中神经降压素浓度最低的患者，治疗前精神病理学水平显著更高。此外，总体精神病理学的改善，尤其是阴性症状的改善与治疗期间脑脊液中神经降压素浓度的增加相关。
结论
这些发现为神经降压素在精神病病理生理学和抗精神病药物作用机制中的作用提供了进一步证据。
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