Ben Arush M W, Roguin A, Zamir E, el-Hassid R, Pries D, Gaitini D, Dale A, Postovsky S
Pediatric Hematology-Oncology Department, Rambam Medical Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Pediatr Hematol Oncol. 1997 Jul-Aug;14(4):381-6. doi: 10.3109/08880019709041598.
Two pediatric oncology patients with Ewing's sarcoma and one with mixed germ cell tumor were treated with drug regimens that included bleomycin or cyclophosphamide. Despite progress to apparently complete remission, all manifested pulmonary nodules on computed tomography during or at the end of treatment. Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide. After cessation of chemotherapy, the pulmonary lesions resolved and all three patients sustained their remissions. The case histories and comments on the diagnosis and management of pulmonary nodules are reviewed.
两名患有尤因肉瘤的儿科肿瘤患者和一名患有混合性生殖细胞肿瘤的患者接受了包含博来霉素或环磷酰胺的药物治疗方案。尽管病情进展至明显完全缓解，但所有患者在治疗期间或治疗结束时的计算机断层扫描中均出现了肺结节。经胸腔镜活检以确认转移，结果却显示为明显归因于博来霉素或环磷酰胺的纤维化病变。化疗停止后，肺部病变消退，所有三名患者均维持了缓解状态。本文回顾了这些病例史以及关于肺结节诊断和管理的评论。
