Drut R, Anderson V, Greco M A, Gutiérrez C, de León-Bojorge B, Menezes D, Peruga A, Quijano G, Ridaura C, Siminovich M, Mayoral P V, Weissenbacher M
Servicio de Patologia, Hospital de Niños, La Plata, Argentina.
Pediatr Pathol Lab Med. 1997 Jul-Aug;17(4):569-76.
The present report describes opportunistic infections found at 74 autopsies of pediatric HIV/AIDS patients performed at several hospitals in Latin American countries. Fungal infections were the most common (53 cases), Candida sp. (39.18%) and Pneumocystis carinii (20.27%) being the most frequently recognized. Other fungal diseases included histoplasmosis, aspergillosis, and cryptococcosis. Viral infections were present in 31 cases, 38.7% being due to cytomegalovirus. Other viruses recognized included herpes simplex and adenovirus. Additional opportunistic infections were due to Mycobacterium avium-intracellulare, toxoplasmosis, and tuberculosis. Nonspecific bacterial bronchopneumonia was present in 11 cases. Cytomegalovirus and P. carinii coinfection was the most common association found. In this series patients died at a younger age (72% at or younger than 1 year old) and there was a slightly higher number of cases of histoplasmosis and brain toxoplasmosis than in other previously published series of infants and children.
本报告描述了在拉丁美洲国家多家医院对74例儿科艾滋病毒/艾滋病患者进行尸检时发现的机会性感染情况。真菌感染最为常见（53例），其中念珠菌属（39.18%）和卡氏肺孢子虫（20.27%）最为常见。其他真菌疾病包括组织胞浆菌病、曲霉病和隐球菌病。病毒感染有31例，其中38.7%是由巨细胞病毒引起的。其他确认的病毒包括单纯疱疹病毒和腺病毒。其他机会性感染是由鸟分枝杆菌复合群、弓形虫病和结核病引起的。非特异性细菌性支气管肺炎有11例。巨细胞病毒和卡氏肺孢子虫合并感染是最常见的关联情况。在这个系列中，患者死亡年龄较小（72%在1岁及以下），与其他先前发表的婴幼儿系列相比，组织胞浆菌病和脑弓形虫病的病例数略多。
