Moffatt M F, Schou C, Faux J A, Cookson W O
Nuffield Department of Medicine, John Radcliffe Hospital, Oxford OX3 9DU, England.
Immunogenetics. 1997;46(3):226-30. doi: 10.1007/s002510050266.
Immunoglobulin E responses to known environmental antigens (allergens) may serve as a general model to investigate germline genetic restriction of the immune response. We have previously shown genetic linkage between IgE responses to major allergens and the T-cell receptor (TCR) A/D locus, but not to TCR-B, implying that elements in TCR A/D restrict the ability to react to specific antigens. We now show, in two sets of subjects from the same population, a strong allelic association between a VA8.1 polymorphism (VA8.1()2) and reactivity to Der p II, a major antigenic component of the house dust mite Dermatophagoides pteronyssinus. Association was also seen between Der p II IgE titres and HLA-DRB1()1501 alleles. Reactivity to Der p II was confined to subjects who were positive for VA8.1()2 and HLA-DRB1()1501, demonstrating germline HLA-DR and TCR-A interaction in restricting the response to exogenous antigen.
对已知环境抗原（过敏原）的免疫球蛋白E反应可作为研究免疫反应种系基因限制的通用模型。我们之前已表明，对主要过敏原的IgE反应与T细胞受体（TCR）A/D基因座之间存在遗传连锁，但与TCR - B无连锁，这意味着TCR A/D中的元件限制了对特定抗原的反应能力。我们现在在来自同一人群的两组受试者中发现，VA8.1多态性（VA8.1()2）与对屋尘螨Der p II（粉尘螨的主要抗原成分）的反应性之间存在强烈的等位基因关联。Der p II IgE滴度与HLA - DRB1()1501等位基因之间也存在关联。对Der p II的反应性仅限于VA8.1()2和HLA - DRB1()1501呈阳性的受试者，这表明种系HLA - DR和TCR - A在限制对外源抗原的反应中存在相互作用。
