Vainrub B, Musher D M
Antimicrob Agents Chemother. 1977 Nov;12(5):625-9. doi: 10.1128/AAC.12.5.625.
Methenamine is frequently prescribed for patients who have chronic urinary infection to suppress bacterial growth during active infection or to prevent recurrence once an infection has been brought under control. We have examined the effect of methenamine mandelate and ascorbic acid on bacteriuria in para- and quadriplegics from a spinal cord unit. Patients with indwelling urinary catheters and those on a program of intermittent catheterization were included. No suppressive or prophylactic effect of this regimen was observed in any of our patients. Methenamine does not appear to be an effective antimicrobial agent in subjects who have an indwelling urinary catheter or in patients with spinal cord injury who are on intermittent catheterization. Since there appears to be reason to question the efficacy of methenamine in situations in which it is usually prescribed, evidence should be sought for a therapeutic effect in other cases. If no benefit is observed, the drug should not be used.
乌洛托品常用于慢性尿路感染患者，以在感染活跃期抑制细菌生长，或在感染得到控制后预防复发。我们研究了扁桃酸乌洛托品和维生素C对脊髓损伤病房截瘫和四肢瘫患者菌尿症的影响。纳入了留置导尿管的患者以及接受间歇性导尿方案的患者。在我们的任何患者中均未观察到该治疗方案的抑制或预防作用。在留置导尿管的患者或接受间歇性导尿的脊髓损伤患者中，乌洛托品似乎不是一种有效的抗菌药物。由于有理由质疑乌洛托品在通常处方情况下的疗效，因此应在其他病例中寻找其治疗效果的证据。如果未观察到益处，则不应使用该药物。
