Muir T E, Tazelaar H D, Colby T V, Myers J L
Division of Anatomic Pathology, Mayo Clinic Rochester, MN 55905, USA.
Mayo Clin Proc. 1997 Jul;72(7):639-42. doi: 10.1016/S0025-6196(11)63569-6.
Diffuse alveolar damage (DAD) is a relatively nonspecific pattern of acute lung injury that can be observed in a wide range of clinical circumstances. DAD has often been recognized in association with various connective tissue diseases; however, to our knowledge, it has not been previously reported in the setting of progressive systemic sclerosis. Herein we describe two patients with established diagnoses of progressive systemic sclerosis who had development of the acute respiratory distress syndrome. Open-lung biopsy specimens from both patients showed a histologic pattern of DAD with no identifiable cause other than their progressive systemic sclerosis. Our results suggest that DAD should be added to the list of pleuropulmonary complications of progressive systemic sclerosis.
弥漫性肺泡损伤（DAD）是一种相对非特异性的急性肺损伤模式，可在多种临床情况下观察到。DAD常与各种结缔组织病相关；然而，据我们所知，此前尚未有在进行性系统性硬化症背景下的相关报道。在此，我们描述了两名已确诊为进行性系统性硬化症且发生急性呼吸窘迫综合征的患者。两名患者的开胸肺活检标本均显示出DAD的组织学模式，除了进行性系统性硬化症外，未发现其他明确病因。我们的结果表明，DAD应被列入进行性系统性硬化症的胸膜肺并发症清单。
