Ishikawa H
Dept. of Cancer Epidemiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
Gan To Kagaku Ryoho. 1997 Jun;24(8):951-7.
I review basic researches and clinical trials on chemoprevention of familial adenomatous polyposis (FAP) which is one of well-known familial cancer. Many basic researches indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) prevent colorectum neoplasms by inhibition of cyclooxygenase (COX) 2. Actually sulindac, which is one of the NSAIDs, reduces adenomas of the rectum of FAP patients. I think, however, sulindac should not be used for cancer prevention, because it can not prevent advanced cancer but it reduces adenomatous polyps of the rectum. Furthermore, side effects of sulindac are frequent and serious.
我回顾了关于家族性腺瘤性息肉病（FAP）化学预防的基础研究和临床试验，FAP是一种著名的家族性癌症。许多基础研究表明，非甾体抗炎药（NSAIDs）通过抑制环氧合酶（COX）2来预防结直肠肿瘤。实际上，舒林酸作为NSAIDs之一，可减少FAP患者直肠腺瘤。然而，我认为舒林酸不应被用于癌症预防，因为它不能预防进展期癌症，只是减少直肠腺瘤性息肉。此外，舒林酸的副作用频繁且严重。
