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2毫克格拉司琼片用于包括顺铂在内的抗癌药物所致恶心和呕吐的临床评价

[Clinical evaluation of 2 mg granisetron tablet for nausea and vomiting induced by anticancer drugs including cisplatin].

作者信息

Takada M, Furuse K, Fukuoka M, Kawahara M, Negoro S, Kusunoki Y, Ogawara M, Furue H

机构信息

2nd Dept. of Internal Medicine, Osaka Prefectural Habikino Hospital (Internal Medicine, Izumisano Municipal Hospital.

出版信息

Gan To Kagaku Ryoho. 1997 Jun;24(8):987-94.

PMID:9212809
Abstract
  1. The clinical efficacy and safety of the 2 mg granisetron tablet were assessed in 32 mainly lung cancer patients who were to receive treatment with anticancer drugs including CDDP. 2. One 2 mg granisetron tablet was administered prophylactically one hour before the start of CDDP administration. 3. Based on the development of nausea and vomiting in 24 hours after the start of CDDP administration, the study medication was judged to be "remarkably effective" or "effective" in 71.0% (22/31) of cases. 4. The study medication was judged to be "safe" in 96.9% (31/32) of cases, without causing any adverse reactions. 5. The above results indicate that the 2 mg granisetron tablet is safe and useful.
摘要
  1. 对32例主要为肺癌且即将接受包括顺铂在内的抗癌药物治疗的患者，评估了2毫克格拉司琼片的临床疗效和安全性。2. 在开始给予顺铂前1小时预防性服用1片2毫克格拉司琼片。3. 根据顺铂给药开始后24小时内恶心和呕吐的发生情况，研究药物在71.0%（22/31）的病例中被判定为“显著有效”或“有效”。4. 研究药物在96.9%（31/32）的病例中被判定为“安全”，未引起任何不良反应。5. 上述结果表明2毫克格拉司琼片安全且有用。

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