Nakahara K, Minami M, Yasumitsu T, Ikeda M, Ohta M, Nakamura K, Akashi A, Kido T
Dept. of Surgery, Otemae Hospital.
Gan To Kagaku Ryoho. 1998 Mar;25(4):571-6.
For patients with pulmo-mediastinal malignancies, the antimetic effect of granisetron was studied in the following two ways. Firstly in the standard method, 40 micrograms/kg of granisetron was infused for 30 minutes, 30 minutes before CDDP infusion. Secondly, in the simultaneous method, granisetron was mixed with CDDP in a 500 microliters infusion bottle, and then infused over 0.5-3 hours. Over a 24-hour time course, significantly effective rates (nausea less than mild, and vomiting 2 times less) were 72.7% in the simultaneous group (n = 22) and 52.6% in the standard group (n = 19). The non-effective rates were 18.2% and 15.8%, respectively. Although the results were not statistically significant, the simultaneous method is easier to perform and it seems to confer a slightly better clinical outcome than the conventional method.
对于患有肺纵隔恶性肿瘤的患者，采用以下两种方式研究了格拉司琼的止吐效果。首先是标准方法，在顺铂输注前30分钟，以40微克/千克的剂量输注格拉司琼30分钟。其次是同步方法，将格拉司琼与顺铂在一个500微升的输液瓶中混合，然后在0.5至3小时内输注。在24小时的时间过程中，同步组（n = 22）的显著有效率（恶心程度小于轻度，呕吐次数减少2次）为72.7%，标准组（n = 19）为52.6%。无效率分别为18.2%和15.8%。虽然结果无统计学意义，但同步方法操作更简便，且似乎比传统方法的临床效果略好。
