Nakazawa T, Takami Y, Benkowski R, Ohtsubo S, Yukio O, Tayama E, Ohtsuka G, Niimi Y, Glueck J, Sueoka A, Schmallegger H, Schima H, Wolner E, Nosé Y
Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
Artif Organs. 1997 Jul;21(7):597-601. doi: 10.1111/j.1525-1594.1997.tb03707.x.
To be able to salvage heart failure patients, the need for an economical permanent ventricular assist device is increasing. To meet this increasing demand, a miniaturized centrifugal blood pump has been developed as a permanently implantable device. The Gyro permanently implantable model (PI-601) incorporates a sealless design with a blood stagnation free structure. The pump impeller is magnetically coupled to the driver magnet in a sealless manner. This pump is atraumatic and antithrombogenic and incorporates a double pivot bearing system. A miniaturized actuator was utilized in this system in collaboration with the University of Vienna. The priming volume of this pump is 20 ml. The overall size of the pump actuator package is 53 mm in height and 65 mm in diameter, 145 ml of displacement volume, and 305 g in weight. Testing to date has included in vitro hydraulic performance and hemolysis. This pump can provide 5 L/min against a 110 mm Hg total pressure head at 2,000 rpm and 8 L/min against 150 mm Hg at 2,500 rpm. The normalized index of hemolysis (NIH) value of this pump was 0.0028 g/100 L at 5 L/min against 100 mm Hg. A preliminary anatomical study revealed the possibility of the implantability of 2 such systems in biventricular bypass at a preperitoneal location. This system is feasible for use as a permanently implantable biventricular assist device.
为了能够挽救心力衰竭患者，对经济实惠的永久性心室辅助装置的需求日益增加。为满足这一日益增长的需求，已开发出一种小型化离心血泵作为可永久植入的装置。陀螺永久性植入模型（PI - 601）采用了无密封设计和无血液停滞结构。泵叶轮以无密封方式与驱动磁体磁耦合。该泵无创伤且抗血栓形成，并采用了双枢轴轴承系统。该系统与维也纳大学合作使用了小型化致动器。该泵的预充量为20毫升。泵致动器组件的整体尺寸为高度53毫米、直径65毫米，排量为145毫升，重量为305克。迄今为止的测试包括体外水力性能和溶血试验。该泵在2000转/分钟时可提供5升/分钟的流量，总压头为110毫米汞柱；在2500转/分钟时可提供8升/分钟的流量，总压头为150毫米汞柱。该泵在5升/分钟、100毫米汞柱的条件下，溶血标准化指数（NIH）值为0.0028克/100升。一项初步解剖学研究表明，在腹膜前位置进行双心室旁路手术时植入2个这样的系统是可行的。该系统作为永久性植入双心室辅助装置是可行的。
