Iida M, Shiono M, Orime Y, Nakata K, Hata M, Sezai A, Yamada H, Kashiwazaki S, Nemoto M, Kinoshita J, Sezai Y
Second Department of Surgery, Nihon University School of Medicine, Tokyo, Japan.
Artif Organs. 1997 Jul;21(7):755-9. doi: 10.1111/j.1525-1594.1997.tb03736.x.
The surface of polypropylene hollow fiber was successfully coated with a very thin (0.2 micron) silicone layer. Experimental studies were performed in long-term (6 h) normothermic cardiopulmonary bypass (CPB) using 10 goats. A conventional membrane oxygenator (Mera Excelung HPO-15H, MERA, Tokyo, Japan) was used for 5 goats as a control (Group C) and a new silicone-coated membrane oxygenator, which is of the same construction as that of the one used for Group C, for 5 (Group S). The O2 transfer and CO2 removal functions showed the same ranges. In the other parameters, there were no differences between the 2 groups. As for hemolysis, however, the plasma free hemoglobin of Group S was lower than that of Group C. Currently, 3 chronic percutaneous cardiopulmonary support (PCPS) experimental models have been conducted, and there has been no evidence of thromboembolism or deterioration of the oxygenator. In conclusion, this new oxygenator is suitable not only for CPB, but also for long-term cardiac support.
聚丙烯中空纤维表面成功涂覆了一层极薄（0.2微米）的硅酮层。使用10只山羊进行了长期（6小时）常温体外循环（CPB）的实验研究。5只山羊使用传统膜式氧合器（Mera Excelung HPO - 15H，日本东京MERA公司）作为对照（C组），另外5只山羊使用与C组所用氧合器结构相同的新型硅酮涂层膜式氧合器（S组）。两组的氧气输送和二氧化碳清除功能范围相同。在其他参数方面，两组之间没有差异。然而，在溶血方面，S组的血浆游离血红蛋白低于C组。目前，已经进行了3个慢性经皮心肺支持（PCPS）实验模型，没有证据表明存在血栓栓塞或氧合器功能恶化。总之，这种新型氧合器不仅适用于CPB，也适用于长期心脏支持。
