Sezai A, Shiono M, Orime Y, Nakata K, Hata M, Yamada H, Iida M, Kashiwazaki S, Kinishita J, Nemoto M, Koujima T, Sezai Y, Saitoh T
Second Department of Surgery, Nihon University School of Medicine, Tokyo, Japan.
Artif Organs. 1997 Jul;21(7):830-5. doi: 10.1111/j.1525-1594.1997.tb03752.x.
We examined left ventricular assist during 6 h for an acute myocardial infarction model in pigs. The outflow cannula was placed in the ascending aorta and an inflow cannula in the left atrium. A pump (Pulsatile group: Zeon Medical and Nonpulsatile group: Nikkiso HPM-15) was connected to each cannula. Items measured were the regional blood flow of the cortex and the medulla in the kidney, renal arterial flow, arterial blood ketone body ratio (AKBR), lactate/pyruvic acid, BUN, creatinine and beta 2-microglobulin. After experimental study, the kidneys were removed, and a pathological study was performed. In the pulsatile assisted group, renal cortical blood flow increased but medulla blood flow decreased. On the other hand, in the nonpulsatile assisted group, both regional blood flows decreased. That means that in the pulsatile assisted group intrarenal redistribution improved, rather than in the nonpulsatile assisted group. The results of our study indicated that pulsatile assist produced superior circulation in the kidney, and the microcirculation on the cell level was superior as well in early treatment of acute left heart failure.
我们在猪急性心肌梗死模型中进行了6小时的左心室辅助研究。流出插管置于升主动脉，流入插管置于左心房。将一台泵（搏动组：Zeon Medical，非搏动组：Nikkiso HPM-15）连接至每个插管。测量的项目包括肾皮质和髓质的局部血流量、肾动脉血流量、动脉血酮体比（AKBR）、乳酸/丙酮酸、尿素氮、肌酐和β2-微球蛋白。实验研究结束后，取出肾脏并进行病理研究。在搏动辅助组中，肾皮质血流量增加但髓质血流量减少。另一方面，在非搏动辅助组中，两个局部血流量均减少。这意味着搏动辅助组肾内血流再分布得到改善，而非搏动辅助组则不然。我们的研究结果表明，搏动辅助在肾脏中产生了更好的循环，并且在急性左心衰竭的早期治疗中，细胞水平的微循环也更好。
