Nakata Kin-Ichi, Shiono Motomi, Orime Yukihiko, Hata Mitumasa, Sezai Akira, Saitoh Toshimi, Sezai Yukiyasu
The Second Department of Surgery, Nihon University School of Medicine, Tokyo, JapanCo-laboratory, Nihon University School of Medicine, Tokyo, Japan.
Artif Organs. 1996 May;20(5):681-684. doi: 10.1111/j.1525-1594.1996.tb04502.x.
To estimate microcirculation of the heart and kidney in pulsatile and nonpulsatile-assisted circulation, a comparison study was done using a swine model. Acute myocardial infarction was made by ligation of the left coronary artery branches. After cardiogenic shock, animals were divided into 3 groups as follows: Group C (n = 6), no assist provided; Group NP (n = 6), assisted by a nonpulsatile pump (Bio-Medicus BP-80); Group P (n = 6), supported by a pulsatile pump (Nippon Zeon). Left coronary artery flow, endocardial and epicardial regional flows, and renal cortex and medulla tissue blood flows were measured. Left coronary artery flow and endocardial and epicardial tissue blood flows decreased in cardiogenic shock, and they recovered to the control level soon after support in both Group N and Group P. Renal medulla and cortex tissue blood flows decreased in cardiogenic shock, and these flows did not recover in either Group N or P. However, cortex blood flow in Group P did improve, but it did not improve in Group N. These results suggested that pulsatile assist was more effective than nonpulsatile assist for microcirculation after cardiogenic shock to avoid deterioration of major organ functions.
为评估搏动性和非搏动性辅助循环下心脏和肾脏的微循环情况，采用猪模型进行了一项对比研究。通过结扎左冠状动脉分支制造急性心肌梗死。心源性休克后，将动物分为以下3组：C组（n = 6），未给予辅助；NP组（n = 6），由非搏动性泵（Bio-Medicus BP-80）辅助；P组（n = 6），由搏动性泵（日本曹达）支持。测量左冠状动脉血流量、心内膜和心外膜局部血流量以及肾皮质和髓质组织血流量。心源性休克时左冠状动脉血流量、心内膜和心外膜组织血流量减少，N组和P组在给予支持后很快恢复至对照水平。心源性休克时肾髓质和皮质组织血流量减少，N组和P组的这些血流量均未恢复。然而，P组的皮质血流量有所改善，而N组则未改善。这些结果表明，对于心源性休克后的微循环，搏动性辅助比非搏动性辅助更有效，可避免主要器官功能恶化。
