Yagame M, Jinde K, Suzuki D, Saotome N, Takano H, Tanabe R, Sato H, Kurokawa K, Sakai H, Matsumae M, Mase H, Harano T
Department of Internal Medicine, Tokai University School of Medicine, Kanagawa.
Intern Med. 1997 May;36(5):351-6. doi: 10.2169/internalmedicine.36.351.
A diabetic patient with hemoglobin (Hb) J-Meerut and low HbA1C levels is reported. An automatic glycohemoglobin analyzer used for the determination of HbA1C revealed an abnormal peak of the peripheral blood obtained from a Japanese female with diabetes. She showed a lower HbA1C level (3.7%) than expected from her fasting plasma glucose (172 mg/dl). High performance liquid chromatography and isoelectric focusing indicated that her abnormal hemoglobin was Hb J-Meerut [alpha 120(H3)Ala-->Glu] and it accounted for 28.3% of the total hemoglobin. Abnormal hemoglobinemia should be considered when a major discrepancy between the levels of HbA1C and fasting plasma glucose is observed.
报告了一名患有血红蛋白（Hb）J-密拉特且糖化血红蛋白（HbA1C）水平较低的糖尿病患者。用于测定HbA1C的自动糖化血红蛋白分析仪显示，一名日本糖尿病女性外周血出现异常峰。她的HbA1C水平（3.7%）低于根据其空腹血糖（172mg/dl）预期的水平。高效液相色谱法和等电聚焦表明，她的异常血红蛋白为Hb J-密拉特[α120（H3）丙氨酸→谷氨酸]，占总血红蛋白的28.3%。当观察到HbA1C水平与空腹血糖水平之间存在重大差异时，应考虑异常血红蛋白血症。
