由耐更昔洛韦的巨细胞病毒引起的进行性视网膜炎-脑炎，与再生障碍性贫血相关。

Progressive retinitis-encephalitis due to ganciclovir-resistant cytomegalovirus associated with aplastic anemia.

作者信息

Sasaki T, Okayama A, Eizuru Y, Murai K, Matsuoka H, Uno H, Minamishima Y, Kataoka H, Koono M, Matsuura Y, Nao-i N, Sawada A, Tachibana N, Tsubouchi H

机构信息

Second Department of Medicine, Miyazaki Medical College.

出版信息

Intern Med. 1997 May;36(5):375-9. doi: 10.2169/internalmedicine.36.375.

DOI:10.2169/internalmedicine.36.375

PMID:9213178

Abstract

A 29-year-old woman with aplastic anemia who complained of visual disturbances and pain in the right eyeball was diagnosed as having cytomegalovirus (CMV) retinitis based upon the characteristic retinal changes and isolation of CMV. She received treatment with ganciclovir (GCV), and the retinitis initially responded for several months. However, the patient was found to have CMV lesions in the left eye followed by neurological symptoms. The CMV isolated just before her death was approximately 20 times more resistant to GCV than that isolated previously, suggesting that the GCV-resistant CMV had developed during the long-term treatment with GCV.

摘要

一名29岁再生障碍性贫血女性患者，主诉视力障碍及右眼球疼痛，基于特征性视网膜改变及巨细胞病毒（CMV）分离，被诊断为患有CMV视网膜炎。她接受了更昔洛韦（GCV）治疗，视网膜炎最初在数月内有反应。然而，该患者左眼发现有CMV病变，随后出现神经症状。在她死前分离出的CMV对GCV的耐药性比之前分离出的毒株高约20倍，提示在长期GCV治疗过程中出现了GCV耐药的CMV。