Shukla R, Srimal R C, Prasad C
Division of Pharmacology, Central Drug Research Institute, Lucknow, India.
Peptides. 1997;18(5):689-93. doi: 10.1016/s0196-9781(97)00130-7.
Cyclo(His-Pro) (CHP) has been shown to facilitate cold-induced hypothermia in the desert rat Mastomys natalensis. In the present study, we examined the role of endogenous CHP in hyperthermia induced by hot ambient temperature (40 degrees C) in the above rodent species. The results of these studies show that housing rodents at 40 degrees C resulted in a altered distribution of CHP in the brain, with a rise in hypothalamic content accompanied by an increase in rectal temperature. While administration of exogenous CHP decreased hyperthermia, immunoneutralization of endogenous CHP increased hyperthermia. The results of these studies show that changes in endogenous CHP levels may affect body temperature regulation.
环（组氨酸-脯氨酸）（CHP）已被证明可促进荒漠大鼠南非乳鼠的冷诱导体温过低。在本研究中，我们研究了内源性CHP在上述啮齿动物物种中由热环境温度（40摄氏度）诱导的体温过高过程中的作用。这些研究结果表明，将啮齿动物饲养在40摄氏度环境中会导致大脑中CHP分布改变，下丘脑含量增加，同时直肠温度升高。外源性CHP给药可降低体温过高，而内源性CHP的免疫中和则会加剧体温过高。这些研究结果表明，内源性CHP水平的变化可能会影响体温调节。
