Afeltra A, Amoroso A, Garzia P, Addessi M A, Pulsoni A, Bonomo L
Department of Clinical Medicine, University of Rome La Sapienza, Italy.
Semin Arthritis Rheum. 1997 Jun;26(6):845-9. doi: 10.1016/s0049-0172(97)80029-7.
The association of systemic lupus erythematosus (SLE) and multiple myeloma (MM) is an uncommon event. We report the relapse of SLE in a patient with a previous history of MM, treated with chemotherapy and, subsequently, with alpha-2b interferon (alpha-2b IFN) as a maintenance therapy. The case is discussed in light of past relevant literature.
The history and clinical, laboratory and radiographic findings of the patient, as well as the subsequent therapeutic approach are discussed. In our review of the literature, journal articles are identified by Medline search.
We describe the case of a woman who developed a multiple myeloma 14 years after a diagnosis of SLE. A careful literature review confirms that the association of these two diseases has been reported only in a few cases. When the plasma cell neoplasia occurred, SLE had been quiescent for several years; the patient was treated with prednisone-melphalan and, subsequently, with alpha-2b IFN as a maintenance therapy. On admission to our department, SLE was in a relapse phase, probably because of IFN treatment. The disease was poorly responsive to steroid therapy and required the use of cytotoxic drugs.
The coexistence of SLE and MM is very rare and the possible pathogenetic mechanisms underlying this association remain unclear. The use of interferon in a patient with an autoimmune disease always invites caution.
系统性红斑狼疮（SLE）与多发性骨髓瘤（MM）的关联是一种罕见情况。我们报告了1例既往有MM病史的患者，该患者接受化疗，随后使用α-2b干扰素（α-2b IFN）作为维持治疗后SLE复发。结合既往相关文献对该病例进行讨论。
讨论该患者的病史、临床、实验室及影像学检查结果，以及后续的治疗方法。在文献回顾中，通过医学文献数据库检索确定期刊文章。
我们描述了1例女性患者，其在诊断SLE 14年后发生多发性骨髓瘤。仔细的文献回顾证实这两种疾病的关联仅在少数病例中有报道。当浆细胞肿瘤形成时，SLE已静止数年；该患者接受泼尼松-美法仑治疗，随后使用α-2b IFN作为维持治疗。入院时，SLE处于复发阶段，可能是由于IFN治疗所致。该疾病对类固醇治疗反应不佳，需要使用细胞毒性药物。
SLE与MM共存非常罕见，这种关联潜在的发病机制仍不清楚。在自身免疫性疾病患者中使用干扰素时需始终谨慎。
