小鼠对嗜林地鼠巴贝斯虫和微小巴贝斯虫感染的免疫特性。

The nature of immunity against Babesia hylomysci and B. microti infections in mice.

作者信息

Hussein H S

出版信息

Ann Trop Med Parasitol. 1977 Sep;71(3):249-53. doi: 10.1080/00034983.1977.11687188.

DOI:10.1080/00034983.1977.11687188

Abstract

Mice which have recovered from Babesia microti infection lose their parasitaemia as soon as three weeks after recovery and become solidly immune. This sterile immunity is not affected by splenectomy and may last for the life of the mouse. Mice which have recovered from B. hylomysci infection continue to harbour parasites at a subpatent level and spontaneous relapses were common after recovery. Hence the type of immunity which developed against this parasite is premunition and may last for life. Such immunity was not absolute and considerable parasitaemias developed after challenge. Cross-protection occurred between the two species of parasite.

摘要

从微小巴贝斯虫感染中恢复的小鼠，在恢复后三周内就会消除寄生虫血症，并获得稳固的免疫力。这种无菌免疫力不受脾切除的影响，可能会持续小鼠一生。从希氏巴贝斯虫感染中恢复的小鼠会继续以亚临床水平携带寄生虫，恢复后自发复发很常见。因此，针对这种寄生虫产生的免疫类型是带虫免疫，可能会持续一生。这种免疫力不是绝对的，攻击后会出现相当程度的寄生虫血症。两种寄生虫之间存在交叉保护作用。