Borris R P
Department of Natural Products Chemistry, Merck Research Laboratories, P. Roy Vagelos Research and Development Center, Rahway, NJ 07065, USA.
J Ethnopharmacol. 1996 Apr;51(1-3):29-38. doi: 10.1016/0378-8741(95)01347-4.
Natural products research continues to provide a tremendous variety of lead structures which are used as templates for the development of new drugs by the pharmaceutical industry. Advances in bioassay technology and in chemical methodology have combined to make natural products a cost effective source for new leads. While microbial products have been the mainstay of industrial natural products discovery, in recent years phytochemistry has again become a field of active interest. Drug discovery programs based on microbial products and phytochemicals are discussed and contrasted.
天然产物研究持续提供种类繁多的先导结构，制药行业将其用作开发新药的模板。生物测定技术和化学方法学的进步相结合，使天然产物成为获取新先导物的经济有效来源。虽然微生物产物一直是工业天然产物发现的主要支柱，但近年来植物化学再次成为一个备受关注的活跃领域。本文讨论并对比了基于微生物产物和植物化学物质的药物发现计划。
