Njoo M D, Westerhof W
Academisch Medisch Centrum, Nederlands Instituut voor Pigmentstoornissen, Amsterdam.
Ned Tijdschr Geneeskd. 1997 Apr 19;141(16):759-64.
Vitiligo is a disorder in which, owing to disappearance of melanocytes in the skin, sharply delimited, symmetrically arranged white patches develop. The condition occurs in 1-2% of the population, mostly between the ages of 10 and 30 years, and as often in males as in females. The course is usually progressive with periods of stability. A number of autoimmune diseases and dermatoses coincide with vitiligo. The cause of vitiligo is unknown. Hereditary factors, autoimmunization, neurological disorders and autodestruction have been hypothesized. Repigmentation therapy consists of photo(chemo)therapy use of corticosteroids, and transplantation of pigment cells. For patients in whom this fails and with more than 80% cutaneous involvement, total depigmentation therapy could be considered.
白癜风是一种由于皮肤中黑素细胞消失而出现边界清晰、对称分布的白色斑块的疾病。该病在1%至2%的人群中出现，大多在10至30岁之间，男女发病率相同。病程通常呈进行性，伴有稳定期。许多自身免疫性疾病和皮肤病与白癜风同时存在。白癜风的病因尚不清楚。已提出遗传因素、自身免疫、神经功能障碍和自身破坏等假说。色素再生疗法包括光（化学）疗法、使用皮质类固醇以及色素细胞移植。对于治疗失败且皮肤受累超过80%的患者，可以考虑进行完全脱色治疗。
