Borgmann R
Nevrologisk avdeling, Haukeland Sykehus, Bergen.
Tidsskr Nor Laegeforen. 1997 May 20;117(13):1889-91.
60 patients have been treated with botulinumtoxin A for cervical dystonia since december 1990. These patients have been seen at 472 visits and received at least two treatments. 55 (92%) patients noted improvement, and marked improvement was noted by 50 out of 60 patients (83%). Further improvement after repeated treatments has been seen up to five years. Only one patient experienced no effect after several treatments with marked improvement. This might have been due to production of antibodies against the toxin. Side effects occurred after 9% of the toxin injections, and dysphagia was the symptom most often reported. The side effects were usually mild and transient, and never gave reason to terminate the treatment.
自1990年12月以来，60例颈肌张力障碍患者接受了A型肉毒毒素治疗。这些患者共接受了472次就诊，且至少接受了两次治疗。55例（92%）患者症状有所改善，60例中有50例（83%）有显著改善。重复治疗后的进一步改善可持续长达五年。只有1例患者经过多次治疗后无明显改善，这可能是由于产生了抗毒素抗体。9%的毒素注射后出现副作用，吞咽困难是最常报告的症状。副作用通常较轻且为一过性，从未导致治疗终止。
