Maehlen J, Heger B, Rostrup M
Patologisk anatomisk avdeling, Ullevål sykehus, Oslo.
Tidsskr Nor Laegeforen. 1997 May 20;117(13):1900-1.
Fatal pneumococcal disease occurred in a young woman with ulcerative colitis that had been quiescent for ten years. Howell-Jolly bodies were present in the peripheral blood smear. Severe atrophy of the spleen (weight 7 g) was discovered at autopsy. The evidence that hyposplenism is associated with inflammatory bowel disease is reviewed and it is suggested that these patients should undergo ultrasound examination and examination of blood smear for detection of functional hyposplenism. We conclude that pneumococcal vaccination should be considered for all patients with inflammatory bowel disease.
一名患有溃疡性结肠炎且病情已缓解十年的年轻女性发生了致命的肺炎球菌疾病。外周血涂片可见豪-焦小体。尸检发现脾脏严重萎缩（重量7克）。本文回顾了脾功能减退与炎症性肠病相关的证据，并建议这些患者应接受超声检查和血涂片检查以检测功能性脾功能减退。我们得出结论，所有炎症性肠病患者均应考虑接种肺炎球菌疫苗。
