Foster K J, Devitt N, Gallagher P J, Abbott R M
Gut. 1982 Jul;23(7):630-2. doi: 10.1136/gut.23.7.630.
This report describes a young woman with ulcerative colitis who developed rapidly fatal pneumococcal septicaemia. Necropsy revealed splenic atrophy. This case supports the hypothesis that splenic atrophy might contribute to the morbidity of ulcerative colitis. The occurrence of splenic atrophy in ulcerative colitis is now well established. Splenic atrophy from other causes has been associated with severe bacterial infections, often pneumococcal. It has been suggested that splenic atrophy is most severe when ulcerative colitis is active and may contribute to postoperative morbidity. This case documents overwhelming septicaemia in a patient with splenic atrophy whose colitis was in remission.
本报告描述了一名患有溃疡性结肠炎的年轻女性，她迅速发展为致命的肺炎球菌败血症。尸检显示脾萎缩。该病例支持脾萎缩可能导致溃疡性结肠炎发病的假说。溃疡性结肠炎中脾萎缩的发生现已得到充分证实。其他原因引起的脾萎缩与严重细菌感染有关，通常是肺炎球菌感染。有人提出，溃疡性结肠炎活动时脾萎缩最为严重，可能导致术后发病。该病例记录了一名脾萎缩患者发生的严重败血症，其结肠炎处于缓解期。
