Leutscher P D, MacKay R, Zachariae H
Peace Corps, Madagaskar.
Ugeskr Laeger. 1997 Jun 16;159(25):3965-7.
A case of phototoxic onycholysis secondary to treatment with doxycycline is presented. Tetracyclines are known to provoke photosensitivity reactions in some individuals exposed to sunlight. The typical photo-toxic manifestation is erythema, but cases with onycholysis have also been reported in the past. With travel to regions with sunny climates it will be important to be aware of the risk of developing onycholysis following the use of tetracyclines and to avoid the most potential phototoxic derivates, especially doxycycline.
本文报告1例多西环素治疗继发的光毒性甲剥离病例。已知四环素会使一些暴露于阳光下的个体发生光敏反应。典型的光毒性表现为红斑，但过去也有甲剥离病例的报道。前往阳光充足地区旅行时，了解使用四环素后发生甲剥离的风险并避免使用最具潜在光毒性的衍生物，尤其是多西环素，非常重要。
