[高碳酸血症诱导实验性高胆红素血症中血脑屏障的可逆性开放]

[Hypercapnia induced reversible opening of the blood-brain barrier in experimental hyperbilirubinemia].

作者信息

Domínguez Ortega F, González Azpeitia G, Cidrás Pidre M, Calvo Rosales J

机构信息

Departamento de Pediatría, Hospital Materno-Infantil, Las Palmas.

出版信息

An Esp Pediatr. 1997 Apr;46(4):374-7.

PMID:9214231

Abstract

OBJECTIVE

The incidence of bilirubin encephalopathy in extremely ill neonates with low serum bilirubin is stimulating interest in factors that can modify the blood-brain barrier permeability and allow the passage of bilirubin-albumin macrocomplexes, which may be produced by hypercapnia.

MATERIALS AND METHODS

Without modifying the normal bilirubin-albumin affinity, we increased cerebral flow by two levels of hypercapnia (PCO2 67.1 and 101.9 mmHg), acquired by inhalation of CO2 enriched air (5 and 15%) and a decrease in pH (7.00 and 6.93).

RESULTS

We demonstrate an increment in cerebral bilirubin deposition (control 2.43 +/- 0.54 mg/g versus 3.29 +/- 0.43 and 3.28 +/- 1.07, F = 4.80, p < 0.05) and I125 albumin (control 26.1 +/- 95.8 micrograms/g versus 364.4 +/- 156.1 and 430.8 +/- 122.4, F03.34, p < 0.05).

摘要

目的

血清胆红素水平低的极危重新生儿中胆红素脑病的发生率引发了人们对可改变血脑屏障通透性并允许胆红素 - 白蛋白大分子复合物通过的因素的兴趣，高碳酸血症可能会产生这种复合物。

材料与方法

在不改变正常胆红素 - 白蛋白亲和力的情况下，我们通过两种高碳酸血症水平（PCO2分别为67.1和101.9 mmHg）增加脑血流量，这是通过吸入富含二氧化碳的空气（5%和15%）并降低pH值（7.00和6.93）实现的。

结果

我们证明脑胆红素沉积增加（对照组为2.43±0.54 mg/g，而高碳酸血症组分别为3.29±0.43和3.28±1.07，F = 4.80，p < 0.05）以及125I白蛋白增加（对照组为26.1±95.8微克/克，而高碳酸血症组分别为364.4±156.1和430.8±122.4，F = 3.34，p < 0.05）。