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鹅肌肽醌A和B:来自粪生真菌嗜粪足孢霉的新型抗真菌和抗菌苯醌类化合物。

Anserinones A and B: new antifungal and antibacterial benzoquinones from the coprophilous fungus Podospora anserina.

作者信息

Wang H, Gloer K B, Gloer J B, Scott J A, Malloch D

机构信息

Department of Chemistry, University of Iowa, Iowa City 52242, USA.

出版信息

J Nat Prod. 1997 Jun;60(6):629-31. doi: 10.1021/np970071k.

DOI:10.1021/np970071k
PMID:9214737
Abstract

Two new benzoquinones with antifungal, antibacterial, and cytotoxic activities have been isolated from liquid cultures of the coprophilous fungus Podospora anserina. The structures of anserinones A (1) and B (2) were assigned on the basis of MS and NMR results, and the absolute stereochemistry of 2 was deduced by analysis of 1H-NMR data for its (R)- and (S)-2-phenylbutyryl ester derivatives.

摘要

从粪生真菌柄孢壳菌的液体培养物中分离出了两种具有抗真菌、抗菌和细胞毒性活性的新苯醌。根据质谱和核磁共振结果确定了柄孢壳菌素A(1)和B(2)的结构,并通过分析其(R)-和(S)-2-苯基丁酰酯衍生物的1H-核磁共振数据推断出2的绝对立体化学。

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