Khan Khalid Mohammed, Saify Zafar Saeed, Shah Syed Tasadaque Ali, Ahmed Mansoor, Saeed Muhammad, Hayat Safdar, Abbas Muhammad, Voelter Wolfgang
Husein Ebrahim Jamal (HEJ) Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.
Arzneimittelforschung. 2002;52(4):286-93. doi: 10.1055/s-0031-1299892.
Thirteen pyridine-3-carboxylic acid salt derivatives with various substituted phenacyl residues were prepared and their cytotoxicity, antibacterial and antifungal activities tested. Compounds 5 and 11 proved to be active in the brine shrimp bioassay, compounds 7, 9-12 and 14 showed promising antibacterial activities, whereas none of the compounds tested against 15 fungal cultures proved to be active. Extensive spectroscopic techniques were employed to confirm the structure of the synthetic products.
制备了13种带有不同取代苯甲酰基残基的吡啶-3-羧酸盐衍生物，并测试了它们的细胞毒性、抗菌和抗真菌活性。化合物5和11在卤虫生物测定中表现出活性，化合物7、9 - 12和14显示出有前景的抗菌活性，而所测试的化合物对15种真菌培养物均无活性。采用了广泛的光谱技术来确认合成产物的结构。
