Dedek W, Schwarz H, Liebaug E
Arch Exp Veterinarmed. 1977;31(3):365-8.
Rafoxanide, labelled by 131J, was applied orally in oily solution to cattle, 2,4 and 12 mg/kg bodymass, resp. The halflifes of degradation in blood is depending on the dosage and is 7 days related to the therapeutical dosage of 5 mg/kg bodymass against Fasciola hepatica. Residues and halflifer in blood, milk, meat and fat are given, related to 131J in the chloroform extract. Rafoxanide does not show persistence following oral application to cattle.
用131J标记的硝碘酚腈以油溶液形式经口给予牛,体重剂量分别为2、4和12mg/kg。血液中降解的半衰期取决于剂量,对于针对肝片吸虫的5mg/kg体重治疗剂量,半衰期为7天。给出了血液、牛奶、肉类和脂肪中的残留量及半衰期,以氯仿提取物中的131J表示。硝碘酚腈经口给予牛后无残留。