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[驱虫药131I-雷复尼特在牛和羊体内的降解与消除]

[Degradation and elimination of the anthelminitic 131I-rafoxanid in cattle and sheep].

作者信息

Dedek W, Schwarz H, Liebaug E

出版信息

Arch Exp Veterinarmed. 1976;30(3):423-6.

PMID:985025
Abstract

Rafoxanide, labelled by 131J, was applied orally in oily solution to cattle and sheep, 12 and 17 mg/kg bodymass, resp. The half time of 131J in blood in 12,5 and 10,5 d for sheep and cattle, resp., the compound is adsorbed to proteins in blood. In the milk a maximal level of 3-3,5 ppm (calculated as total 131J) after 4-6 d was measured. More detailed results regarding the metabolism of rafoxanide are hitherto not possible.

摘要

用¹³¹I标记的硝碘酚腈以油溶液形式经口给予牛和羊,剂量分别为12毫克/千克体重和17毫克/千克体重。¹³¹I在羊和牛血液中的半衰期分别为12.5天和10.5天,该化合物可吸附于血液中的蛋白质。在牛奶中,4 - 6天后测得最高含量为3 - 3.5 ppm(以¹³¹I总量计算)。迄今为止,关于硝碘酚腈代谢的更详细结果尚无法得出。

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