Hanion-Lundberg K M, Kirby R S, Gandhi S, Broekhuizen F F
University of Wisconsin Medical School Milwaukee Clinical Campus, USA.
Am J Obstet Gynecol. 1997 Jun;176(6):1149-54; discussion 1154-6. doi: 10.1016/s0002-9378(97)70328-4.
This study aims to establish normal values for nucleated red blood cells in term singletons and factors associated with their elevation.
Cord blood was prospectively collected from term singleton gestations from Feb. 1 to July 31, 1995. Umbilical vein white blood cells and nucleated red blood cells were counted and umbilical arterial pH was determined. Medical records provided maternal and neonatal information.
Cord blood from 1112 cases was obtained and evaluated for nucleated red blood cells per 100 white blood cells. Nine outliers were censored (nucleated red blood cells per 100 white blood cells = 126 to 830); five cases were excluded because of missing data. The mean value of nucleated red blood cells per 100 white blood cells was 8.55, the SD was 10.27, and the range was 0 to 89. The value did not very by maternal tobacco or drug use, anemia, fetal presentation, or mode of delivery. Both maternal diabetes and meconium were associated with elevated values, p < 0.01. Apgar scores and cord pHs showed trends toward inverse proportionality to the number of nucleated red blood cells per 100 white blood cells.
The mean number of nucleated red blood cells per 100 white blood cells was 8.55, with a wide range and SD. Elevated values may be associated with markers of intrauterine hypoxia such as meconium, lower Apgar scores, and lower pH values.
本研究旨在确定足月单胎新生儿有核红细胞的正常值及其升高的相关因素。
前瞻性收集1995年2月1日至7月31日足月单胎妊娠的脐血。计数脐静脉白细胞和有核红细胞，并测定脐动脉pH值。病历提供了母亲和新生儿的信息。
获取了1112例病例的脐血，并对每100个白细胞中的有核红细胞进行评估。剔除9例异常值（每100个白细胞中有核红细胞数 = 126至830）；5例因数据缺失被排除。每100个白细胞中有核红细胞的平均值为8.55，标准差为10.27，范围为0至89。该值不受母亲吸烟、吸毒、贫血、胎儿先露或分娩方式的影响。母亲患糖尿病和胎粪污染均与该值升高有关，p < 0.01。阿氏评分和脐血pH值与每100个白细胞中有核红细胞数呈反比趋势。
每100个白细胞中有核红细胞的平均数量为8.55，范围和标准差较大。升高的值可能与宫内缺氧的标志物有关，如胎粪、较低的阿氏评分和较低的pH值。
