Athen D, Beckmann H, Ackenheil M, Markianos M
Arch Psychiatr Nervenkr (1970). 1977 Oct 11;224(2):129-40. doi: 10.1007/BF00346481.
In eight male patients with alcoholic delirium concentrations of 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovannilic acid (HVA) in CSF, activity of dopamine-beta-hydroxylase (DBH) and urinary excretion of noradrenaline (NA), adrenaline (A), and dopamine (DA) were measured during the delirium and a drug-free control period. MHPG concentration in CSF, excretion of NA and A as well as activity of serum DBH were significantly elevated during the delirium phase as compared to the control period. Urinary DA excretion and HVA in CSF did not show any constant changes. There was a positive correlation (r = 0.64) between DBH activity and the intensity of the delirium (as measured on the delirium rating scale). It is hypothesized that there is a relationship between alcoholic delirium and increased central noradrenergic activity.
在8例酒精性谵妄男性患者中，于谵妄期及无药物治疗的对照期测定了脑脊液中3-甲氧基-4-羟基苯乙二醇（MHPG）和高香草酸（HVA）的浓度、多巴胺-β-羟化酶（DBH）的活性以及去甲肾上腺素（NA）、肾上腺素（A）和多巴胺（DA）的尿排泄量。与对照期相比，谵妄期脑脊液中MHPG浓度、NA和A的排泄量以及血清DBH活性均显著升高。脑脊液中尿DA排泄量和HVA未显示出任何持续变化。DBH活性与谵妄强度（根据谵妄评定量表测量）之间存在正相关（r = 0.64）。据推测，酒精性谵妄与中枢去甲肾上腺素能活性增加之间存在关联。
