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在一家以学术医院为基础的老年医学实践中,老年患者使用地高辛、利尿剂、β受体阻滞剂、血管紧张素转换酶抑制剂和钙通道阻滞剂的情况。

Use of digoxin, diuretics, beta blockers, angiotensin-converting enzyme inhibitors, and calcium channel blockers in older patients in an academic hospital-based geriatrics practice.

作者信息

Fishkind D, Paris B E, Aronow W S

机构信息

Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA.

出版信息

J Am Geriatr Soc. 1997 Jul;45(7):809-12. doi: 10.1111/j.1532-5415.1997.tb01506.x.

Abstract

OBJECTIVE

To investigate the prevalence of and indications for digoxin use and the prevalence of beta blocker and calcium channel blocker use in older patients with previous myocardial infarction or coronary artery disease (CAD), and the prevalence of use of diuretics, beta blockers, angiotensin-converting enzyme (ACE) inhibitors, and calcium channel blockers in older patients with hypertension in an academic hospital-based geriatrics practice.

DESIGN

A retrospective analysis of charts from 528 unselected older patients, seen from June 1995 through July 1996 at an academic hospital-based geriatrics practice, was performed to investigate the prevalence of digoxin use and indications for digoxin use, the prevalence of beta blocker and calcium channel blocker use in older patients with previous myocardial infarction or coronary artery disease (CAD), and the prevalence of use of diuretics, beta blockers, angiotensin-converting enzyme (ACE) inhibitors, and calcium channel blockers in older patients with hypertension.

SETTING

An academic hospital-based, primary care geriatrics practice staffed by fellows in a geriatrics training program and full-time faculty geriatricians.

PATIENTS

A total of 416 women and 112 men, mean age 81 +/- 8 years (range 58 to 101), were included in the study.

MEASUREMENTS AND MAIN RESULTS

Ninety-two of the 528 patients (17%) were taking digoxin. Recorded indications for digoxin were atrial fibrillation with or without congestive heart failure (CHF) in 39% of patients, CHF with sinus rhythm and abnormal left ventricular ejection fraction (LVEF) in 18% of patients, a clinical assessment of CHF with sinus rhythm and no recorded measurement of LVEF in 20% of patients, paroxysmal atrial fibrillation in 14% of patients, and coronary artery disease (CAD) in 9% of patients. Of 121 patients with previous myocardial infarction, 23 (19%) were prescribed beta blockers, and 54 (45%) were taking calcium channel blockers. Of 173 patients with CAD, 41 (24%) were treated with beta blockers, and 79 (46%) were taking calcium channel blockers. LVEF was not recorded in the charts of 90 of 121 patients (74%) with prior myocardial infarction and of 125 of 173 patients (72%) with CAD. Of 480 older patients with hypertension, 154 (37%) were treated with diuretics, 55 (13%) were treated with beta blockers, 160 (38%) were treated with ACE inhibitors, and 197 (47%) were treated with calcium channel blockers.

CONCLUSIONS

In 528 older patients seen in an academic hospital-based geriatrics practice, the prevalence of digoxin use was 19%. Appropriate indications for digoxin were documented clearly in the charts of 53 of 92 patients (57%). Calcium channel blockers were used more often than beta blockers in patients with previous myocardial infarction or CAD. Calcium channel blockers were the most frequently used antihypertensive drugs.

摘要

目的

调查曾患心肌梗死或冠心病(CAD)的老年患者中地高辛的使用情况及使用指征,以及β受体阻滞剂和钙通道阻滞剂的使用情况;同时调查在一家以学术医院为基础的老年医学诊所中,老年高血压患者使用利尿剂、β受体阻滞剂、血管紧张素转换酶(ACE)抑制剂和钙通道阻滞剂的情况。

设计

对1995年6月至1996年7月期间在一家以学术医院为基础的老年医学诊所就诊的528例未经挑选的老年患者的病历进行回顾性分析,以调查地高辛的使用情况及使用指征,曾患心肌梗死或冠心病(CAD)的老年患者中β受体阻滞剂和钙通道阻滞剂的使用情况,以及老年高血压患者使用利尿剂、β受体阻滞剂、血管紧张素转换酶(ACE)抑制剂和钙通道阻滞剂的情况。

地点

一家以学术医院为基础的初级保健老年医学诊所,由老年医学培训项目的研究员和全职老年医学教员提供服务。

患者

本研究共纳入416名女性和112名男性,平均年龄81±8岁(范围58至101岁)。

测量与主要结果

528例患者中有92例(17%)正在服用地高辛。记录的地高辛使用指征为:伴有或不伴有充血性心力衰竭(CHF)的心房颤动,占患者的39%;窦性心律且左心室射血分数(LVEF)异常的CHF,占患者的18%;临床评估为窦性心律的CHF且未记录LVEF测量值,占患者的20%;阵发性心房颤动,占患者的14%;冠心病(CAD),占患者的9%。在121例曾患心肌梗死的患者中,23例(19%)被处方使用β受体阻滞剂,54例(45%)正在服用钙通道阻滞剂。在173例CAD患者中,41例(24%)接受β受体阻滞剂治疗,79例(46%)正在服用钙通道阻滞剂。在121例曾患心肌梗死的患者中,90例(74%)的病历未记录LVEF;在173例CAD患者中,125例(72%)的病历未记录LVEF。在480例老年高血压患者中,154例(37%)接受利尿剂治疗,55例(13%)接受β受体阻滞剂治疗,160例(38%)接受ACE抑制剂治疗,197例(47%)接受钙通道阻滞剂治疗。

结论

在一家以学术医院为基础的老年医学诊所就诊的528例老年患者中,地高辛的使用率为19%。92例患者中有53例(57%)的病历明确记录了地高辛的合理使用指征。在曾患心肌梗死或CAD的患者中,钙通道阻滞剂的使用频率高于β受体阻滞剂。钙通道阻滞剂是最常用的抗高血压药物。

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