Nordborg M, Donnelly P
Department of Ecology and Evolution, University of Chicago, Illinois 60637-1573, USA.
Genetics. 1997 Jul;146(3):1185-95. doi: 10.1093/genetics/146.3.1185.
A method of estimating the selfing rate using DNA sequence data was recently proposed by Milligan. Unfortunately, a number of errors make interpretation of his results problematic. In the present paper we first show how the usual coalescent process can be adapted to models that include selfing, and then use this result to find moment estimators as well as the likelihood surface for the selfing rate, s, and the scaled mutation rate, theta. We conclude that, regardless of the method used, large sample sizes are necessary to estimate s with any degree of certainty, and that the estimate is always highly sensitive to recent changes in the true value.
米利根最近提出了一种利用DNA序列数据估算自交率的方法。不幸的是，一些错误使得对其结果的解读存在问题。在本文中，我们首先展示了通常的合并过程如何适用于包含自交的模型，然后利用这一结果找到自交率s和标度突变率θ的矩估计量以及似然曲面。我们得出结论，无论使用何种方法，都需要大样本量才能有一定把握地估计s，并且该估计值总是对真实值的近期变化高度敏感。
