Fu Y X
Human Genetics Center, University of Texas, Houston 77225, USA.
Genetics. 1997 Aug;146(4):1489-99. doi: 10.1093/genetics/146.4.1489.
A coalescent theory for a sample of DNA sequences from a partially selfing diploid population and an algorithm for simulating such samples are developed in this article. Approximate formulas are given for the expectation and the variance of the number of segregating sites in a sample of k sequences from n individuals. Several new estimators of the important parameters theta = 4N mu and the selfing rate s, where N and mu are, respectively, the effective population size and the mutation rate per sequence per generation, are proposed and their sampling properties are studied.
本文提出了一种针对部分自交二倍体群体的DNA序列样本的合并理论，以及一种用于模拟此类样本的算法。给出了从n个个体的k个序列样本中分离位点数量的期望和方差的近似公式。提出了几个重要参数theta = 4N mu和自交率s的新估计量，其中N和mu分别是有效群体大小和每代每个序列的突变率，并研究了它们的抽样性质。
