基于基因座间关联的中性检验。
A test of neutrality based on interlocus associations.
作者信息
Kelly J K
机构信息
Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA.
出版信息
Genetics. 1997 Jul;146(3):1197-206. doi: 10.1093/genetics/146.3.1197.
Abstract
The evolutionary processes governing variability within genomic regions of low recombination have been the focus of many studies. Here, I investigate the statistical properties of a measure of interlocus genetic associations under the assumption that mutations are selectively neutral and sites are completely linked. This measure, denoted ZnS, is based on the squared correlation of allelic identity at pairs of polymorphic sites. Upper bounds for ZnS are determined by simulations. Various deviations from the neutral model, including several different forms of natural selection, will inflate the value of ZnS relative to its neutral theory expectations. Larger than expected values of ZnS are observed in genetic samples from the yellow-ac-scute and Adh regions of Drosophila melanogaster.
摘要
控制低重组基因组区域内变异性的进化过程一直是许多研究的重点。在此，我在突变是选择性中性且位点完全连锁的假设下，研究一种基因座间遗传关联度量的统计特性。这种度量表示为ZnS，基于多态性位点对之间等位基因同一性的平方相关性。通过模拟确定ZnS的上限。与中性模型的各种偏差，包括几种不同形式的自然选择，将使ZnS的值相对于其中性理论预期值升高。在黑腹果蝇的黄色 - ac - 急腹片和乙醇脱氢酶区域的遗传样本中观察到ZnS值高于预期。
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