Kageyama T, Nishikido N, Honda Y, Kurokawa Y, Imai H, Kobayashi T, Kaneko T, Kabuto M
Urban Environment and Health Project, National Institute for Environmental Studies, Ibaraki, Japan.
Int Arch Occup Environ Health. 1997;69(6):447-54. doi: 10.1007/s004200050173.
In order to examine the effects of mild to moderate obesity, moderate to heavy smoking, and moderate alcohol consumption on cardiac parasympathetic activities and systemic sympathetic activities, a cross-sectional survey was carried out in 282 healthy Japanese male white-collar workers. Their autonomic activities were assessed as amplitudes of spectral components of heart rate variability (HRV) which was measured in the annual physical examination at their work sites. Taking the effects of aging on HRV into account, the cardiac parasympathetic activity at supine rest and its response to a change in posture were reduced in mildly to moderately obese subjects with a body mass index of 21-36, whereas the sympathetic activity was not. The effects of smoking and alcohol consumption on HRV were not confirmed. The above results means that we should consider obesity as a covariate when we examine possible relationships between cardiac parasympathetic activity and other environmental factors. There is a need for further studies on the relationships among obesity, change in parasympathetic activity, and development of health problems. The dose-effect relationships between long-term smoking or alcohol consumption and chronic changes in autonomic activities also remain to be determined.
为了研究轻度至中度肥胖、中度至重度吸烟和适度饮酒对心脏副交感神经活动和全身交感神经活动的影响，对282名健康的日本男性白领进行了一项横断面调查。他们的自主神经活动通过心率变异性（HRV）频谱成分的幅度进行评估，HRV是在他们工作场所的年度体检中测量的。考虑到衰老对HRV的影响，体重指数为21-36的轻度至中度肥胖受试者在仰卧休息时的心脏副交感神经活动及其对姿势变化的反应降低，而交感神经活动则没有。吸烟和饮酒对HRV的影响未得到证实。上述结果意味着，当我们研究心脏副交感神经活动与其他环境因素之间的可能关系时，应将肥胖视为一个协变量。有必要进一步研究肥胖、副交感神经活动变化与健康问题发展之间的关系。长期吸烟或饮酒与自主神经活动慢性变化之间的剂量-效应关系也有待确定。
