Rajkumar Sarah, Schmidt-Trucksäss Arno, Wellenius Gregory A, Bauer Georg F, Huynh Cong Khanh, Moeller Alexander, Röösli Martin
Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051, Basel, Switzerland.
Int J Public Health. 2014 Aug;59(4):577-85. doi: 10.1007/s00038-014-0545-y. Epub 2014 Feb 7.
To investigate the effect of a change in second-hand smoke (SHS) exposure on heart rate variability (HRV) and pulse wave velocity (PWV), this study utilized a quasi-experimental setting when a smoking ban was introduced.
HRV, a quantitative marker of autonomic activity of the nervous system, and PWV, a marker of arterial stiffness, were measured in 55 non-smoking hospitality workers before and 3-12 months after a smoking ban and compared to a control group that did not experience an exposure change. SHS exposure was determined with a nicotine-specific badge and expressed as inhaled cigarette equivalents per day (CE/d).
PWV and HRV parameters significantly changed in a dose-dependent manner in the intervention group as compared to the control group. A one CE/d decrease was associated with a 2.3% (95% CI 0.2-4.4; p = 0.031) higher root mean square of successive differences (RMSSD), a 5.7% (95% CI 0.9-10.2; p = 0.02) higher high-frequency component and a 0.72% (95% CI 0.40-1.05; p < 0.001) lower PWV.
PWV and HRV significantly improved after introducing smoke-free workplaces indicating a decreased cardiovascular risk.
为研究二手烟暴露变化对心率变异性（HRV）和脉搏波速度（PWV）的影响，本研究在实施禁烟令时采用了准实验设置。
在55名非吸烟的酒店工作人员禁烟前及禁烟后3至12个月测量了自主神经系统活动的定量指标HRV和动脉僵硬度指标PWV，并与未经历暴露变化的对照组进行比较。二手烟暴露通过尼古丁特异性徽章测定，并以每天吸入的香烟当量（CE/d）表示。
与对照组相比，干预组的PWV和HRV参数以剂量依赖方式显著变化。每天CE/d降低1与连续差值均方根（RMSSD）升高2.3%（95%CI 0.2 - 4.4；p = 0.031）、高频成分升高5.7%（95%CI 0.9 - 10.2；p = 0.02）以及PWV降低0.72%（95%CI 0.40 - 1.05；p < 0.001）相关。
引入无烟工作场所后，PWV和HRV显著改善，表明心血管风险降低。
