Bown N P, Rowe D, Reid M M
Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom.
Cancer Genet Cytogenet. 1997 Jul 15;96(2):115-7. doi: 10.1016/s0165-4608(96)00280-4.
Granulocytic sarcomas are localized deposits of myeloid leukemia cells that may precede or occur concurrently with disseminated disease. In either event, the origins of the cells comprising the malignancy are the same. Published reports of granulocytic sarcomas have described, in the majority of cases, a morphology typical of AML-M2 and the presence of the t(8;21)(q22;q21) typical of that FAB type. In a smaller number of cases, the inv(16)(p13q22) characteristic of AML-M4 has been recorded in cells with a myelomonocytic appearance. We report two patients with granulocytic sarcomas showing monocytic morphology in which the malignant cells showed t(9;11)(p22;q23) typical of AML-M5. This abnormality is seen in up to 7% of childhood AML, but has not previously been reported in granulocytic sarcoma. The detection of this cytogenetic abnormality facilitated the precise characterization of the malignant cells and selection of the most appropriate therapy, emphasizing the value of cytogenetic analysis in cases of granulocytic sarcoma.
粒细胞肉瘤是髓系白血病细胞的局限性沉积，可先于播散性疾病出现或与之同时发生。无论哪种情况，构成恶性肿瘤的细胞起源都是相同的。已发表的粒细胞肉瘤报告在大多数病例中描述了典型的AML-M2形态以及该FAB类型典型的t(8;21)(q22;q21)。在少数病例中，具有粒单核细胞外观的细胞中记录到了AML-M4特征性的inv(16)(p13q22)。我们报告了两名具有单核细胞形态的粒细胞肉瘤患者，其中恶性细胞显示出AML-M5典型的t(9;11)(p22;q23)。这种异常在高达7%的儿童AML中可见，但此前在粒细胞肉瘤中尚未有报道。这种细胞遗传学异常的检测有助于对恶性细胞进行精确表征并选择最合适的治疗方法，强调了细胞遗传学分析在粒细胞肉瘤病例中的价值。
