Bronzetti G, Della Croce C, Aretini P, Fiorio R
Istituto di Mutagenesi e Differenziamento, Centro Nazionale delle Ricerche, Pisa, Italy.
J Environ Pathol Toxicol Oncol. 1996;15(2-4):59-64.
Cancer development is a multistage process wherein mutational events play an important role. Various antimutagen components, in particular magnesium and selenium, have been reported to have anticarcinogenic properties. These two oligoelements display different behaviors according to their concentrations. The different effects of magnesium and selenium depend on the different mechanisms of cell absorption. The importance of antimutagenesis studies in cancer prevention is reported and a review of the basic mechanisms operative in antimutagenesis, including some data on known antimutagens, is made.
癌症发展是一个多阶段过程，其中突变事件起着重要作用。据报道，各种抗诱变成分，特别是镁和硒，具有抗癌特性。这两种微量元素根据其浓度表现出不同的行为。镁和硒的不同作用取决于细胞吸收的不同机制。本文报道了抗诱变研究在癌症预防中的重要性，并对抗诱变作用的基本机制进行了综述，包括一些已知抗诱变剂的数据。
