Khudoleĭ V V
Vestn Ross Akad Med Nauk. 1993(1):34-41.
The problems of anticarcinogenesis are discussed in the context of mechanistic approaches and the well-known mechanisms of multistage carcinogenesis. Various events at extra- and intracellular levels are involved in mutagenesis and carcinogenesis. The most promising candidates for suppression of chemical carcinogenesis are some nitrosation modifiers, dietary sorbents, metabolic activation modulators, reactive metabolite trappers, repair inducers, gene expression inhibitors, etc. Short-term tests for mutagenicity are more preferable for screening potential anticarcinogenic agents. The bioassays for anticarcinogenesis should be assessed for sensitivity, specificity and predictability and the genetic profiles of the antimutagenic activity of the modifiers analysed.
在多阶段致癌作用的机制方法和知名机制的背景下讨论了抗癌作用的问题。细胞外和细胞内水平的各种事件参与了诱变和致癌过程。抑制化学致癌作用最有前景的候选物质是一些亚硝化修饰剂、膳食吸附剂、代谢激活调节剂、活性代谢物捕获剂、修复诱导剂、基因表达抑制剂等。短期诱变性试验更适合筛选潜在的抗癌剂。应评估抗癌作用的生物测定的敏感性、特异性和可预测性，并分析修饰剂抗诱变活性的遗传谱。
