Evrensel T, Manavoğlu O, Ozyardimci C, Gülten M, Nak S G, Yerci O
Department of Oncology, Uludağ University Medical School, Bursa, Turkey.
J Environ Pathol Toxicol Oncol. 1996;15(2-4):215-9.
Gastric carcinoma of the intestinal type is assumed to develop from precancerous gastric lesions. It is now widely accepted that Helicobacter pylori (HP) infection causes chronic gastritis and, after a period of time, intestinal metaplasia (IM). It was suggested that these gastric lesions may evolve into gastric carcinoma after a lengthy latency period. HP seropositivity is high in Turkey at early ages. This may explain the high incidence of gastric carcinoma in this geographic region. In this study, we examine the relationship between HP and IM in endoscopic gastric biopsy specimens. We examined 840 biopsies taken from 210 patients. HP positivity and the presence of IM were examined in these specimens by histopathologic methods. HP positivity was also determined by CLO testing. HP was positive in 156 of the 210 patients examined (74.3%). The distribution of HP seropositivity did not differ between age groups (p > 0.05). IM was present in 101 patients in the entire study group (48%). Among the 156 HP-positive patients, the rate of IM was 44.8% (n = 70). The rate of IM among the 54 HP-negative patients was 57.4% (n = 31), which was not statistically significant (p > 0.05). IM positivity has been shown to increase in older age, which was statistically significant (p < 0.001). We were not able to show a relationship between HP seropositivity and IM. Increased HP seropositivity at an early age is a common risk factor in our population. We must consider other factors that may contribute to the increased rate of IM in older age groups.
肠型胃癌被认为是由癌前胃病变发展而来。目前已广泛接受幽门螺杆菌（HP）感染会导致慢性胃炎，并在一段时间后引发肠化生（IM）。有人提出，这些胃部病变可能在漫长的潜伏期后演变成胃癌。在土耳其，HP血清阳性在早年人群中的比例很高。这可能解释了该地理区域胃癌的高发病率。在本研究中，我们检查了内镜下胃活检标本中HP与IM之间的关系。我们检查了从210名患者身上获取的840份活检样本。通过组织病理学方法检查这些样本中的HP阳性情况和IM的存在情况。HP阳性也通过CLO检测来确定。在接受检查的210名患者中，有156名HP呈阳性（74.3%）。HP血清阳性的分布在各年龄组之间没有差异（p>0.05）。在整个研究组中，有101名患者存在IM（48%）。在156名HP阳性患者中，IM的发生率为44.8%（n=70）。在54名HP阴性患者中，IM的发生率为57.4%（n=31），差异无统计学意义（p>0.05）。IM阳性率已显示在老年人群中增加，这具有统计学意义（p<0.001）。我们未能显示出HP血清阳性与IM之间的关系。早年HP血清阳性率增加是我们人群中的一个常见风险因素。我们必须考虑其他可能导致老年组IM发生率增加的因素。
