Yee Yuk Kei, Wong Ka Wah, Hui Chee Kin, Chan Chi Kuen, Chan Annie O O, Lam Shiu Kam, Fung Fiona M Y, Hung Ivan, Wong Benjamin C Y
Department of Medicine, The University of Hong Kong, Hong Kong.
J Gastroenterol Hepatol. 2009 May;24(5):896-9. doi: 10.1111/j.1440-1746.2009.05799.x.
Upper endoscopy records from 1998 to 2003 were reviewed. The demographic data, endoscopic diagnosis, results of rapid urease test and the absence or presence of intestinal metaplasia (IM) in histology were reviewed, to evaluate the prevalence of IM and Helicobacter pylori (Hp) infection over time in Hong Kong.
Among 1805 endoscopies performed, 1751 had both rapid urease test and histology available. A significant drop in the prevalence of duodenal ulcers from 17.9% in 1998 to 9.8% in 2003 was found (P = 0.015). Prevalence of IM was 13.9%, 5.9% and 9.4% in Hp positive, Hp negative and overall respectively (P < 0.05). The prevalence of IM increased with age, and the patterns were similar amongst subjects in 1998-2000 and those in 2001-2003. There was progressive decrease in Hp prevalence from 58% in 1998 to 40% in 2001 (P = 0.014), but no further decrease was seen in 2002-3. There was no corresponding decrease in IM prevalence. Instead IM prevalence in 2002-2003 was significantly higher than the prevalence in previous few years (P = 0.04).
The prevalence of IM did not change in the period from 1998 to 2003 despite a drop in the prevalence of Hp infection since 1994.
回顾了1998年至2003年的上消化道内镜检查记录。对人口统计学数据、内镜诊断、快速尿素酶试验结果以及组织学中肠化生（IM）的有无进行了回顾，以评估香港地区IM和幽门螺杆菌（Hp）感染随时间的流行情况。
在1805例进行的内镜检查中，1751例同时有快速尿素酶试验和组织学检查结果。发现十二指肠溃疡的患病率从1998年的17.9%显著下降至2003年的9.8%（P = 0.015）。Hp阳性、Hp阴性及总体人群中IM的患病率分别为13.9%、5.9%和9.4%（P < 0.05）。IM的患病率随年龄增加，1998 - 2000年和2001 - 2003年的人群模式相似。Hp患病率从1998年的58%逐渐下降至2001年的40%（P = 0.014），但在2002 - 2003年未见进一步下降。IM患病率没有相应下降。相反，2002 - 2003年的IM患病率显著高于前几年（P = 0.04）。
尽管自1994年以来Hp感染率有所下降，但1998年至2003年期间IM的患病率没有变化。
