The exfoliating epithelial surface of the uterine cervix. IV: Scanning electron microscopical study in invasive squamous carcinoma of human subjects.

The exfoliating epithelial surface of 15 invasive squamous carcinomas of the uterine cervix was investigated with the aid of the scanning electron microscope (SEM). At low magnification (less than or equal to 5,000 X) thirteen tumors presented irregular cobblestone-like structures and the remaining two, irregular intermediate formations (i.e. between cobblestones and mosaics). Cellular overlapping was found in three tumors. At higher magnifications (up to 25,000 X) all 15 tumors showed irregular disorganized structures such as bizarre microvilli with or without fragmented microrugae. Seven tumors had in addition tall finger-shaped protrusions and two rumors crater-like formations covered by irregular microvilli. The SEM structure found in invasive squamous carcinoma differed from the SEM structures earlier reported for the normal squamous or glandular epithelium, squamous metaplasia, dysplasia or carcinoma in situ of the uterine cervix.