Rubio C A
Anat Rec. 1976 Jul;185(3):359-72. doi: 10.1002/ar.1091850308.
The exfoliating epithelial surface of the ectocervix (pars vaginalis) and the vagina from normal mice was studied by scanning electron microscopy during the four main phases of the ovulatory cycle, and after estrogen administration. At proestrus, the epithelial surface usually presented cobblestone-like structure furnished with thin microvilli; at estrus, large, flat mosaics covered by long, convoluted microrugae; at metestrus, the presenting cellular surfaces were of intermediate size (i.e., between cobblestone and mosaics) having fragmented microrugae; and at diestrus, by mosaics or intermediate structures covered by microvilli. Estrogen administration to intact and oophorectomized animals resulted in flat mosaics and large numbers of loosely attached cells with rolled-up borders which permitted the observation of the basal surface of the cells. In those animals the apical aspect of the cells which lined the lumen showed convoluted microrugae with circular configuration, while the basal aspect of such cells had club-tipped microvilli. The findings were correlated with post-scanning histological examination in all animals.
在排卵周期的四个主要阶段以及给予雌激素后，通过扫描电子显微镜对正常小鼠的宫颈外口（阴道部）和阴道的脱落上皮表面进行了研究。在动情前期，上皮表面通常呈现出带有细小微绒毛的鹅卵石样结构；在发情期，大的扁平镶嵌体被长而卷曲的微嵴覆盖；在动情后期，呈现的细胞表面大小居中（即介于鹅卵石样和镶嵌体之间），有破碎的微嵴；在间情期，则由微绒毛覆盖的镶嵌体或中间结构组成。对完整和去卵巢动物给予雌激素后，会出现扁平镶嵌体以及大量边缘卷曲的松散附着细胞，从而能够观察到细胞的基底面。在那些动物中，衬于管腔的细胞顶端呈现出具有圆形形态的卷曲微嵴，而此类细胞的基底端则有杵状微绒毛。对所有动物的扫描后组织学检查结果均与上述发现相关。
