Radulovacki M, Trbovic S M, Carley D W
Department of Pharmacology, College of Medicine, University of Illinois at Chicago, 60612, USA.
Exp Neurol. 1997 Jun;145(2 Pt 1):371-5. doi: 10.1006/exnr.1997.6460.
We characterized the effects of 48 h of rapid-eye-movement (REM) sleep deprivation on cardiovascular and respiratory variables and on sleep-related cardiopulmonary interactions in adult male Sprague-Dawley rats. Rats were instrumented for monitoring EEG, EMG, and aortic blood pressure. Respiratory rate and minute ventilation were measured by unrestrained single-chamber plethysmography. By using radiotelemetry to monitor blood pressure we clearly demonstrated progressive decreases in mean blood pressure with transitions from wakefulness to non-rapid-eye-movement and REM sleep which were unaffected by REM sleep deprivation. Mirror-image state-dependent increases in heart period suggest that baroreflexes were augmented during sleep with respect to wakefulness. REM sleep deprivation was also associated with lower blood pressure and longer heart period over all sleep/wake states, although this achieved statistical significance only during REM sleep and only during the first hour of recovery sleep. These cardiovascular changes coupled with the observed decreases in respiratory rate and minute ventilation suggest a further augmentation of baroreflexes following REM sleep deprivation.
我们研究了成年雄性Sprague-Dawley大鼠快速眼动（REM）睡眠剥夺48小时对心血管和呼吸变量以及睡眠相关心肺相互作用的影响。对大鼠进行仪器安装以监测脑电图（EEG）、肌电图（EMG）和主动脉血压。通过无束缚单腔体积描记法测量呼吸频率和分钟通气量。通过使用无线电遥测技术监测血压，我们清楚地证明，从清醒状态转变为非快速眼动睡眠和快速眼动睡眠时，平均血压会逐渐下降，而快速眼动睡眠剥夺对此没有影响。与镜像状态相关的心动周期增加表明，与清醒状态相比，睡眠期间压力反射增强。快速眼动睡眠剥夺还与所有睡眠/清醒状态下较低的血压和较长的心动周期有关，尽管这仅在快速眼动睡眠期间以及恢复睡眠的第一小时才具有统计学意义。这些心血管变化，再加上观察到的呼吸频率和分钟通气量的降低，表明快速眼动睡眠剥夺后压力反射进一步增强。
