Krstić C, Radojicić B
Bilt Hematol Transfuz. 1977;5(1):69-73.
The effects of Prednisone therapy at two patients with pernicious anemia were studied on haematologic response, gastric secretion and gastric mucosal hystology. The treatment resulted in each case in correctin of the megaloblastic to normoblastic erythropoesis, and increse in reticulocytes, hemoglobin level and red cell count. Schilling-s test was normalised in one case that means that Prednison enchanced B12 absorption. Gastric secretion of acid and gastric hystology were not respond during the Prednisone therapy. It was discused about immunological problems in pernicious anemia which are very important and required continued investigations.
研究了泼尼松治疗两名恶性贫血患者对血液学反应、胃分泌及胃黏膜组织学的影响。治疗在每例患者中均使巨幼红细胞生成转变为正常红细胞生成，并使网织红细胞、血红蛋白水平及红细胞计数增加。一例患者的希林试验恢复正常，这意味着泼尼松增强了维生素B12的吸收。泼尼松治疗期间胃酸分泌及胃组织学无反应。文中讨论了恶性贫血中非常重要且需要持续研究的免疫学问题。
